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Telomere shortening deficiency

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Humans are multicellular organism because we are made up of multiple cells (cells make up tissue, which makes up an organ, which makes up an organ system, which makes up our body).

What are telomeres?

Telomere is an essential part of human cells that affect how our cells age. Telomeres are a specific sequence of DNA that forms a cap at the two ends of each chromosome. This cap – like the plastic cap on the end of a shoelace – keeps the chromosome from fraying each time it is replicated. When a cell divides, it replicates everything inside of it, including its chromosomes – the bundles of DNA that provide the genetic blueprint for building and running your body.

 

Telomere also protect genetic information during cell division because a short piece of each chromosome is lost every time DNA is replicated. Without telomeres to protect them, chromosomes get increasingly tangled and damaged, resulting in poorly constructed cells and speeding up the process that leads to cell death. This, in turn, means an older, less resistant body.

This is the reason telomeres are so important in context of successful cell division: They “cap” the end-sequences and themselves get lost in the process of DNA replication. But the cell has an enzyme called telomerase, which carries out the task of adding repetitive nucleotide sequences to the ends of the DNA.

Telomeres are repetitive nucleotide sequences at each end of chromosomes. Their function is to protect the ends of the chromosomes from deterioration or fusion to other chromosomes during cell division. With every cell division, telomeres shorten. Telomere shortening is involved in all aspects of the aging process on a cellular level. Telomere length represents our biological age as opposed to our chronological age

Telomere shortening deficiency

There has been growing evidence that lifestyle factors may affect the health and lifespan of an individual by affecting telomere length. The purpose of this review was to highlight the importance of telomeres in human health and aging and to summarize possible lifestyle factors that may affect health and longevity by altering the rate of telomere shortening.

Recent studies indicate that telomere length, which can be affected by various lifestyle factors, can affect the pace of aging and onset of age-associated diseases.

5 ways to encourage telomere lengthening and delay shortening

1. Maintain a healthy weight. Research has found obesity as an indicator of shorter telomeres. …
2. Exercise regularly. …
3. Manage chronic stress. …
4. Eat a telomere-protective diet. …
5. Incorporate supplements.

Telomere length shortens with age. Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual.

Shorter telomeres have been associated with increased incidence of diseases and poor survival. The rate of telomere shortening can be either increased or decreased by specific lifestyle factors.

Better choice of diet and activities has great potential to reduce the rate of telomere shortening or at least prevent excessive telomere attrition, leading to delayed onset of age-associated diseases and increased lifespan. This review highlights the role of telomeres in aging and describes the lifestyle factors which may affect telomeres, human health, and aging.

Now we know, Telomeres become shortened over time as a cell divides and replicates. They can be prematurely shortened due to oxidation, inflammation, and stress. These conditions reduce the protective effect of telomeres, damage DNA, contribute to early cell death, and may be the key to the root cause – and prevention – of age-related conditions.

Defective telomeres are now being linked to dozens of diseases. Studying telomeres, the structures that protect the ends of chromosomes. It has become a key issue because shorter telomeres have been associated with cardiovascular disease, inflammatory disorders, metabolic syndrome, diabetes, cognitive decline, and other chronic degenerative conditions normally associated with aging.

Lifestyle changes including nutrition aimed at reducing inflammation may help aid in delaying telomere shortening.

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